Novel physiological functions of free fatty acid receptors
نویسندگان
چکیده
منابع مشابه
Complex Pharmacology of Free Fatty Acid Receptors.
G protein-coupled receptors (GPCRs) are historically the most successful family of drug targets. In recent times it has become clear that the pharmacology of these receptors is far more complex than previously imagined. Understanding of the pharmacological regulation of GPCRs now extends beyond simple competitive agonism or antagonism by ligands interacting with the orthosteric binding site of ...
متن کاملFree fatty acid receptors and drug discovery.
Utilizing the human genome database, the recently developed G-protein-coupled receptor (GPCR) deorphanizing strategy successfully identified multiple receptors of free fatty acids (FFAs) and is proposed to play a critical role in a variety of physiologic homeostasis mechanisms. GPR40 and GPR120 are activated by medium- and long-chain FFAs, whereas GPR41 and GPR43 are activated by short-chain FF...
متن کاملNutritional Signaling via Free Fatty Acid Receptors.
Excess energy is stored primarily as triglycerides, which are mobilized when demand for energy arises. Dysfunction of energy balance by excess food intake leads to metabolic diseases, such as obesity and diabetes. Free fatty acids (FFAs) provided by dietary fat are not only important nutrients, but also contribute key physiological functions via FFA receptor (FFAR)-mediated signaling molecules,...
متن کاملNovel physiological functions of oligosaccharides*
This paper reviews the evidence for novel physiological functions of oligosaccharides. A history of the research and development and the types of health benefits are discussed. A key property of the physiological functions lies in the indigestibility of oligosaccharides, which gives rise to fermentation in the large intestine, followed by an increase of Bifidobacteria and short-chain fatty acid...
متن کاملInternational Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions.
Identification of G protein-coupled receptors that are activated by free fatty acids has led to considerable interest in their pharmacology and function because of the wide range of normal physiology and disease states in which fatty acids have been implicated. Free fatty acid receptor (FFA) 1 is activated by medium- to long-chain fatty acids and is expressed in the insulin-producing beta-cells...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2021
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.94.0_3-s25-3